Drug induced agranulocytosis pdf

Analgesics and nonsteroidal antiinflammatory drugs. It results in a severe reduction of granulocytes in the peripheral blood with an absolute neutrophil count anc of under 0. Pdf agranulocytosis associated with dipyrone metamizol. State of art of idiosyncratic druginduced neutropenia or. Pdf the etiology, epidemiology and management of idiosyncratic. Druginduced neutropenia and agranulocytosis uptodate. Patients with such severe neutropenia are likely to. Diagnosis and management of idiopathic druginduced and. The meeting resulted in proposed standard designations of blood cytopenias and criteria for causality assessment of neutropenia, thrombocytopenia and aplastic anemia. Druginduced agranulocytosis is related to certain classes of drugs and is represented in the literature chiefly as single case reports of a descriptive nature. At a glance drug induced neutropenia is characterized by a decline in absolute neutrophil counts precipitated by exposure to a medication. A serious side effect of antithyroid drug use, however, is agranulocytosis. However, the mortality rate during the acute phase is high, and therefore prompt supportive therapy with isolation and broadspectrum antibiotics for infection are mandatory during periods of severe neutropenia.

Druginduced agranulocytosis is a rare, potentially fatal idiosyncratic reaction that. Drugs related to idiosyncratic neutropenia and agranulocytosis. It occurs es pecially in association with the use of antithyroid drugs, metamizole. Idiosyncratic druginduced agranulocytosis or acute. Antithyroid drug atd induced agranulocytosis is a rare but lifethreatening adverse drug reaction that occurs in patients during the treatment of graves disease. Druginduced agranulocytosis is usually a selflimiting condition provided toxic drugs are withdrawn with complete resolution within two weeks. In this chapter, we report and discuss the diagnosis and management of idiosyncratic druginduced, or drugassociated, severe neutropenia, and. The mechanisms of the neutropenia are varied and the propensity to infection depends upon the adequacy of bone marrow reserve. Idiosyncratic druginduced agranulocytosis or acute neutropenia is an adverse event resulting in a neutrophil count of under 0.

Neutropenia can occur at any time during the course of. Idiosyncratic druginduced agranulocytosis diag is an adverse reaction to drugs due to abnormal susceptibility, peculiar to the individual. Agranulocytosis including fatal cases has been reported with other agents in the class. Antithyroid drug therapy is the standard treatment for this disease, especially in young women of reproductive age. Aplastic anemia is the leading cause of death followed by thrombocytopenia, agranulocytosis, and hemolytic anemia. Agranulocytosis associated with dipyrone metamizol article pdf available in european journal of clinical pharmacology 6011. Druginduced agranulocytosis drug and therapeutics bulletin. Pdf on jan 1, 2018, natasa colovic and others published druginduced agranulocytosis. Most but not all instances of agranulocytosis result from exposure to drugs. Druginduced agranulocytosis in the outpatient setting is a rare but potentially fatal adverse effect of many classes of medications. The quantification of the incidence of potentially druginduced agranulocytosis in general, and in particular its association with single drugs, requires studies on large populations and the use of strict epidemiological methodology to prevent reporting of grossly biased results. It frequently occurs as idiosyncratic adverse drug reaction. Possible risk factors for leukopenia and neutropenia include preexisting low white blood cell count wbc or absolute neutrophil count anc and history of drug induced leukopenia or neutropenia. Others causes of acquired neutropenia, such as primary immune mechanisms, chemotherapy, and infections, as well as congenital neutropenia in children are discussed separately.